It has successfully been proven for the first time that the modification of PF resins with protein-containing components, which are by-products in wheat preparation, enable the manufacture of virtually formaldehyde-free wood-based panels with high moisture resistance. Upon condensing 10 to 30 % of this natural component, phenol-resin content could be equally substituted. This means that such a bonding system contains fewer synthetic components, which, in the long run, also contributes to preserving the limited fossil oil and gas resources. Phenol resins that are established and are available on today’s market make the manufacture of extremely low-formaldehyde wood-based materials possible, which also, without any restrictions, meet the Japanese requirements of F**** quality. By applying the developed resin system, the formaldehyde content of the manufactured particleboards, OSB and MDF could additionally be reduced to about a tenth [1, 2, 3] when compared to traditional phenol systems. Both laboratory and industrial testing revealed that the addition of proteins did not result in obvious deterioration of any mechanical or hygric parameters.